Research Articles
CAR-T Cell Engineering for Resistant Cancers: A 2024 Comparative Analysis of Efficacy Across Construct Designs
This article provides a comprehensive, comparative analysis of chimeric antigen receptor (CAR) T-cell constructs engineered to overcome treatment resistance in relapsed/refractory cancers.
ESR1 Mutations in Breast Cancer: Mechanisms of Hormone Therapy Resistance and Next-Generation Therapeutic Strategies
This comprehensive review addresses the critical role of ESR1 mutations in driving resistance to endocrine therapy for hormone receptor-positive (HR+) metastatic breast cancer.
ELISpot Assay in Cancer Immunotherapy: A Complete Guide to Monitoring T-Cell Responses in Research & Clinical Trials
This comprehensive guide explores the ELISpot (Enzyme-Linked Immunospot) assay as a critical tool for monitoring antigen-specific immune responses in cancer research and immunotherapy development.
EGFR Heterogeneity and Intrinsic Drug Tolerance: Mechanisms, Detection, and Therapeutic Implications
This article explores the critical role of epidermal growth factor receptor (EGFR) heterogeneity in the development of intrinsic drug tolerance in cancers such as non-small cell lung cancer (NSCLC).
AI-Driven Digital Pathology Quantification vs. Traditional IHC Scoring: A Complete Guide for Precision Research
This article provides a comprehensive analysis for researchers and drug development professionals on the paradigm shift from traditional, semi-quantitative immunohistochemistry (IHC) scoring to AI-powered digital pathology quantification.
Decoding Cancer Origins: A Comprehensive Guide to DNA Methylation Signature Analysis for Researchers
This article provides a comprehensive overview for researchers, scientists, and drug development professionals on the use of DNA methylation signatures for predicting a cancer's tissue of origin.
Breaking the Barrier: Mechanisms of CD8+ T Cell Infiltration in Cold vs. Hot Tumors and Therapeutic Implications
This comprehensive review synthesizes current research on the biological mechanisms that govern cytotoxic CD8+ T lymphocyte infiltration into solid tumors, a critical determinant of immunotherapy response.
Decoding the Tumor Microenvironment: A Comprehensive Guide to Cytokine Profiling with Luminex Technology
This article provides a detailed guide for researchers and drug development professionals on leveraging multiplex bead-based immunoassays (Luminex xMAP technology) for cytokine profiling within the complex tumor microenvironment (TME).
LGR5 as a Universal Cancer Stem Cell Marker: Evidence, Applications, and Cross-Cancer Validation
This review synthesizes the latest evidence for Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) as a pan-cancer cancer stem cell (CSC) marker.
CPOP Framework Explained: Predicting Multi-Omics Data Across Platforms for Precision Medicine
This article provides a comprehensive guide to the Cross-Platform Omics Prediction (CPOP) statistical framework, designed for researchers and drug development professionals.